Report details a rare case of acquired hemophilia secondary to immune checkpoint inhibition

Report details a rare case of acquired hemophilia secondary to immune checkpoint inhibition

This uncommon immune-related antagonistic occasion was beforehand reported solely 4 occasions within the context of immune checkpoint inhibitor (ICI) therapy.

a Status Report Posted in JTO Scientific and Analysis Stories The affected person tells what occurred Hemophilia A Throughout therapy with immune checkpoint inhibitors (ICI). This uncommon immune-related antagonistic occasion (irAE) was beforehand reported solely 4 occasions in the middle of ICI therapy.

Acquired hemophilia A (AHA) happens when a affected person develops autoantibodies to issue VIII (FVIII) however doesn’t have a historical past of bleeding issues. Hemophilia is characterised by spontaneous bleeding occasions which may be life-threatening, and as much as half of AHA instances might have unknown origins. Whereas it’s uncommon, AHA has been linked to autoimmune or inflammatory ailments and different situations.

The case report marks the fifth time that the AHA has been documented within the context of ICI use. A 56-year-old man identified with in depth stage SCLC (ES-SCLC) was given 4 programs of palliative remedy together with carboplatin, etoposide and atezolizumab. Subsequent CT scans confirmed a big partial system response. After 16 months of illness management on atzolizumab, the affected person developed asymptomatic regular anemia. An outpatient hematological examination and blood transfusion had been carried out.

Hematological examination confirmed recurrent anemia and acquisition of a possible FVIII inhibitor, though there was no scientific proof of bleeding, bruising, or growth of SCLC or decompensated liver illness. AHA was identified primarily based on decreased FVIII exercise and different indicators of acquired FVIII inhibitors. On this case, the AHA was extra more likely to be an irAE an infection primarily based on the usage of atezolizumab and no indicators that the situation may need arisen from different recognized causes.

Blood transfusion was the primary administration technique, then coagulation issue correction and suppression of issue inhibition had been carried out. Atezolizumab has additionally been discontinued. Per week later, the affected person returned to the hospital with a hematoma of the left higher extremity and chest wall. He initially responded to prednisone, then continued to take prednisone whereas receiving transfusion assist.

Though initially responding to therapy, the hematoma progressed, and the left shoulder confirmed new hematoma on imaging research. The affected person acquired 3 doses of activated recombinant issue VII over 6 hours, then took 100g of rituximab weekly earlier than discharge from hospital.

Prednisone was lowered to fifteen mg and over the following 4 weeks, a complete of 4 doses of rituximab got. Three months after preliminary presentation, positron emission tomography with CT confirmed a whole metabolic response and there have been no additional bleeding occasions.

This case, taken along with the earlier 4 reported instances of ICI-induced AHA, exhibits that though uncommon, such intense radiation can happen and has been efficiently handled with hemostatic agent assist in addition to immunosuppression. Escalating immunosuppression – on this case with rituximab – was additionally efficient and inside printed tips. On this case and others, the elevated activated partial thromboplastin time was persistent and issue VIII (FVIII) inhibitors remained for months, even after scientific enhancements.

AHA has additionally been related to ES-SCLC itself, and the authors spotlight one other case of AHA secondary to ES-SCLC however earlier than therapy. AHA was efficiently handled with corticosteroids to remove the FVIII inhibitor earlier than chemotherapy, and the illness was beneath management for greater than a yr with out a recurrence of the FVIII inhibitor. Consideration of a paraneoplastic trigger is necessary when diagnosing AHA after ICI use, however it may be tough to distinguish.

Total, the case highlights the opportunity of acute an infection with the usage of ICSI and the significance of doctor consciousness.

The authors concluded, “Clinicians needs to be alert to the opportunity of extreme immune-associated hematological toxicity secondary to ICIs.” “Immune-mediated administration of AHA was per printed tips, and so far, all reported instances have proven enchancment with supporting brokers and immunosuppression.” Extra analysis remains to be wanted to find out the long-term outcomes of AHA secondary to ICIs.


Fletcher J, Chicken R, McLean A, O’Byrne Ok, Xu W. Acquired hemophilia secondary to immune checkpoint inhibitor: a case report. JTO Clin Res. Revealed on-line September 19, 2022. doi: 10.1016 / j.jtocrr.2022.100409

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